In January, citing a need to focus on its core brands, Summit suspended publication of 30,000-circ. Bank Advisor magazine.Whelan said Summit has since formed a partnership with fellow trade publisher Source Media in which Source acquired certain rights associated with Mortgage Originator Magazine. The partnership allows Source, which publishes Origination News magazine, to fulfill MOM’s subscriptions and take on its advertisers through the end of the year.Financial terms of the partnership were not disclosed.“It’s a win-win for both of us,” said Whelan. A Source spokesperson did not immediately return requests for comment.According to Whelan, Summit still owns the titles and rights to the publication, and could consider a relaunch “at some point.” But that “most likely wouldn’t be before January 2011, at least,” he said. Summit Business Media has suspended publication of monthly financial title Mortgage Originator Magazine. The June issue will be its last.Launched nearly 20 years ago, Mortgage Originator carried a paid and controlled circulation of 15,000. Summit acquired the magazine about a decade ago.“It’s a strong brand that was an acknowledged, established part of our portfolio,” Summit senior vice president John Whelan told FOLIO:. “But, it’s been caught in the eye of the storm in terms of the worsening economic conditions. The readership has been impacted heavily.”An editor and an independent sales manager were laid off as a result of the closure, Whelan said. Group publisher John DeCesare will remain with the company.
John Jordan/The Texas TribuneA new mobile app launched after Santa Fe High School shooting last month will allow Texans to report on suspicious activity happening in their own communities and schools. The iWatchTexas app, introduced this week, will help Texans report potential crimes, terrorism or threats to school safety, according to Gov. Greg Abbott, who directed the Department of Public Safety to develop the app. “Our law enforcement officers often rely on vigilant Texans to help keep communities safe, and this new tool will give everyone the ability to quickly and easily communicate with authorities and help prevent future tragedies,” Abbott said in a news release Friday announcing the app.The app can now be downloaded from the App Store for iPhone users and Google Play for Android users. Plans were already underway for the app before the shooting three weeks ago at Santa Fe High School, which left 10 people dead and 10 others injured. Afterward, Abbott introduced a school safety plan that called for expanding the app’s use “to enable and encourage parents, students and teachers to easily report potential harm or criminal activity directed at school students, school employees, and schools.”The plan also called for more school protections and mental health screenings. In addition, Abbott asked lawmakers to consider “red-flag laws,” which allows judges to temporarily seize a person’s firearms if they’re considered an imminent threat. Reporting a threat on the app can take fewer than five minutes, and reports are reviewed by law enforcement analysts after they’re submitted, according to the Department of Public Safety. Officials suggest citizens may report suspicious activity like strangers asking questions about building security features and procedures, unusual chemical smells or vehicles left in no-parking zones at important buildings.“Amid the growing threats to public safety by malicious actors, we want to remind the public that they can be law enforcement’s greatest resource to combat those intent on harming others, including innocent schoolchildren and administrators,” said Steven McCraw, the director of the Department of Public Safety. Officials noted that all reports are confidential, but the app is not meant to be used to report emergencies — those seeking immediate help should call 911. Share
Share Photo via FlickrNet Neutrality repeal took place six months after the FCC voted to undo the rules that barred telecommunications companies from favoring their own services over those from rivals .Your ability to watch and use your favorite apps and services could start to change — though not right away — following the official demise Monday of Obama-era internet protections.Any changes are likely to happen slowly, as companies assess how much consumers will tolerate.The repeal of “net neutrality” took effect six months after the Federal Communications Commission voted to undo the rules, which had barred broadband and cellphone companies from favoring their own services and discriminating against rivals such as Netflix.Internet providers such as AT&T, Verizon and Comcast had to treat all traffic equally. They couldn’t slow down or block websites and apps of their choosing. Nor could they charge Netflix and other video services extra to reach viewers more smoothly. The rules also barred a broadband provider from, say, slowing down Amazon’s shopping site to extract business concessions.#NetNeutrality’s old rules are a thing of the past. Here’s what could happen next https://t.co/paJGiIbE53 pic.twitter.com/UxcyrLuxnH— USA TODAY (@USATODAY) June 11, 2018 For now, broadband providers insist they won’t do anything that would harm the “internet experience” for consumers. Most currently have service terms that specify they won’t give preferential treatment to certain websites and services, including their own.However, companies are likely to drop these self-imposed restrictions; they will just wait until people aren’t paying a lot of attention, said Marc Martin, a former FCC staffer who is now chairman of communications practice at the law firm Perkins Coie. Any changes now, while the spotlight is on net neutrality, could lead to a public relations backlash.Companies are likely to start testing the boundaries over the next six months to a year. Expect to see more offers like AT&T’s exemption of its DirecTV Now streaming TV service from customers’ mobile data limits. Rival services like Sling TV and Netflix count video against data caps, essentially making them more expensive to watch.Although the FCC issued a report in January 2017 saying such arrangements, known as “zero rating,” are probably anti-consumer, the agency did not require companies to change their practices right away. After President Donald Trump appointed a new chairman to the FCC, the agency reversed its stance on zero rating and proceeded to kill net neutrality.Critics of net neutrality, including the Trump administration, say such rules impeded companies’ ability to adapt to a quickly evolving internet.But consumer advocates say that the repeal is just pandering to big business and that cable and phone giants will now be free to block access to services they don’t like. They can also set up “fast lanes” for preferred services — in turn, relegating everyone else to “slow lanes.” Tech companies such as Netflix, Spotify and Snap echoed similar concerns in regulatory filings.Martin said broadband providers probably won’t mess with existing services like Netflix, as that could alienate consumers.But they could start charging extra for services not yet offered. For instance, they might charge more to view high-resolution “4K” video, while offering lower-quality video for free. The fees would be paid by the video services, such as Hulu, and could be passed along to consumers in higher subscription rates.More than 20 states sued the government to stop the repeal, as did the public-interest group Free Press and the think tank Open Technology Institute and Firefox browser maker Mozilla.Washington and Oregon now have their own net neutrality laws, and a bill is pending in California’s legislature.That’s another reason companies are likely to move slowly, at least at first.“They don’t want to add fuel to the fire,” Martin said. By MAE ANDERSON, AP Technology Writer The repeal of #NetNeutrality officially goes into effect today, but the fight is far from over.The people saying we can’t pass the resolution to #SaveTheInternet in the House are the same people who were saying we couldn’t do it in the Senate.Ignore them. Just keep fighting.— Ed Markey (@SenMarkey) June 11, 2018 Now, all that is legal as long as companies post their policies online.The change comes as broadband and cellphone providers expand their efforts to deliver video and other content to consumers.With net neutrality rules gone, AT&T and Verizon can give priority to their own movies and TV shows, while hurting rivals such as Amazon, YouTube and startups yet to be born.The battle isn’t entirely over, though. Some states are moving to restore net neutrality, and lawsuits are pending. Also, the Senate voted to save net neutrality, though that effort isn’t likely to become law.The @FCC’s handover of the free and open internet to Big Telecom starts today.Except we are suing.23 AGs are working together to block the illegal rollback of #netneutrality—so we can save the internet as we know it. https://t.co/eSezj8fwkd— New York Attorney General (@NewYorkStateAG) June 11, 2018
X Listen Share 00:00 /00:47 Laura Isensee/Houston Public MediaThe college-advising program EMERGE has taken new steps to support students not just to get into selective universities, but to thrive on campus.About 200 Houston-area students gathered this weekend to gear up for college and form a support network, reflecting a new effort to improve the experience for first generation college students.The idea emerged from a situation last year, when a Houston student at an elite college in the Pacific Northwest almost turned around and came back home because she felt so lonely. But then her college-advising program EMERGE connected her with two other students on campus who were from Houston and had graduated from local charter schools, YES Prep and KIPP. They bonded and helped each other get through their first year.Now, EMERGE, YES Prep and KIPP have come together to collaborate and extend this kind of support to more students, with a focus on first generation college students.“For our students who are coming from first generation, low-income backgrounds landing on a selective college campus can be very overwhelming,” said Felicia Martin, who directs college success initiatives at EMERGE.“They’re not seeing students like them, they’re not seeing students with the same background as them, so it can be very isolating pretty quickly.” Through the new collaboration, there are now more than 50 “squads” for nearly 200 Houston-area students headed to the same college or out-of-state region, including Brown, Duke and Boston universities.Since 2010, EMERGE has helped high-achieving students from under-served communities attend selective universities. National research shows that these students are often overlooked by elite colleges and miss out attending them, even though they have the grades and talent to succeed and despite the fact that generous financial packages mean the elite degree would cost them less. EMERGE now partners with several local districts, including Houston, Spring Branch and Spring to support over 1,000 students in high school and more already in college.Martin said that the new squads reflect the fact that more first generation students are getting access to higher education. But they don’t always find the support that they need when they arrive on campus. “I think the ideal outcome is that students see each other as a resource — someone to be an active listener or bounce ideas off of so they can access resources,” she said.The model follows an idea from the scholarship program from the Posse Foundation. It sends students from under-represented communities, including from Houston, to partner schools in groups or “posses,” including the University of Texas at Austin, Texas A&M and Trinity University.Cathy Horn, a professor at the University of Houston, previously told News 88.7 that that the value of that peer support shouldn’t be underestimated.“One of the important things that we know from research is that your success in college depends a lot on your sense of belonging on the campus you find yourself,” Horn said in a previous interview. To embed this piece of audio in your site, please use this code:
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Insight into how pharmaceutical solvents diffuse through a human nail (2015, June 19) retrieved 18 August 2019 from https://phys.org/news/2015-06-insight-pharmaceutical-solvents-diffuse-human.html In a recent study, Wing Sin Chiu, Natalie A. Belsey, Natalie L. Garrett, Julian Moger, M. Begoña Delgado-Charro, and Richard H. Guy from the University of Bath and the University of Exeter developed a method to acquire real-time semi-quantitative data on solvent diffusion through a human nail using stimulated Raman scattering microscopy. Their research appears in the Proceedings of the National Academy of Sciences.Human skin, hair, and nails are made of a hard, fibrous protein called keratin. Keratin provides a protective barrier keeping unwanted compounds from easily entering the body. However, keratin’s ability to protect the body also makes it an obstacle for topical drug delivery. Up to now, it has only been possible to obtain time- and position-dependent data on the movement of chemicals through the outermost 20μm of the nail. In an effort to better understand the diffusion of key pharmaceutical solvents through a nail, Chiu et al. used stimulated Raman spectroscopy (SRS) to trace the movement of dimethylsulfoxide (DMSO), propylene glycol (PG), and water through several human nail samples.Stimulated Raman spectroscopy is an imaging technique that was first reported in 2008 for detecting small amounts of chemicals, such as pharmaceuticals or metabolites, within biological systems without having to use fluorescent labels. Since SRS is based on matching laser frequencies to chemical vibrational frequencies, it is able to neglect the environmental background, making it a good technique for non-invasive biomedical studies. Furthermore, SRS scan time is fast enough for real-time measurements. Explore further Journal information: Proceedings of the National Academy of Sciences For D2O, the Raman wavelengths were tuned to the O-D stretching band at 2,500 cm-1. Signals were taken as a function of time (every 2.7 minutes after t=10 minutes). After about thirty-five minutes, D2O had diffused ~100μm into the nail. The authors report that this is the first time that this kind of rapid, real-time transport of water through a nail has been visualized.Studies with deuterated DMSO and PG showed that they took much longer to diffuse through the nail. While water took less than an hour to penetrate 100μm, after a day, DMSO and PG only penetrated 40-50μm into the nail.Data analysis showed that the solvents deviate from classical diffusion behavior as the time of diffusion increases. Quantitative analysis was performed by accounting for several factors, including nail curvature, sample movement, and solvent depletion at the surface. Scans were normalized to keratin’s –CH2 frequency and analyses showed no significant solvent depletion at the nail surface. For each of the solvents, as diffusion time increased, the concentration profile deviated from classical behavior (Fick’s Second Law). Based on calculations using experimental results, this behavior is characteristic of a time- and concentration-dependent diffusion coefficient. Additionally, the rapid diffusion of water compared to the other two solvents indicates that there is a likely a strong molecular size dependence on diffusion across the nail. Finally, SEM imaging confirmed that the solvents loosen the nail structure and increase nail roughness, indicating that the nail is weakened when exposed to the solvents for a long period of time, which may lead to increased solvent diffusion over time. Additional studies of the nanostructure of the nail may provide further insight as to why solvent diffusion into a human nail deviates from classical behavior.This paper reports for the first time real-time solvent behavior as it is absorbed into a human nail. These results elucidate certain factors in drug solvent and nail bed uptake that will help in drug discovery and the development of topical medicines for nail disease. Play Orthogonal views of D2O penetration into human nail as a function of time. Credit: PNAS, doi: 10.1073/pnas.1503791112 Keratin has a characteristic –CH2 stretch at 2,855 cm-1 that Chiu et al. used to normalize SRS signals from the nail samples. Studies were conducted using deuterated solvents to easily distinguish the solvent vibrational bands from those of the nail. Concentration is linearly related to SRS signal allowing for a semi-quantitative measurement of solvent diffusion. This technique is “semi-quantitative” because of signal attenuation from light scattering as sample depth increases. In this case, signals from deeper within the nail would underestimate the amount of chemical present because the signal is slightly weakened with increasing depth. More information: “Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy” PNAS, DOI: 10.1073/pnas.1503791112AbstractThe effective treatment of diseases of the nail remains an important unmet medical need, primarily because of poor drug delivery. To address this challenge, the diffusion, in real time, of topically applied chemicals into the human nail has been visualized and characterized using stimulated Raman scattering (SRS) microscopy. Deuterated water (D2O), propylene glycol (PG-d8), and dimethyl sulphoxide (DMSO-d6) were separately applied to the dorsal surface of human nail samples. SRS microscopy was used to image D2O, PG-d8/DMSO-d6, and the nail through the O-D, -CD2, and -CH2 bond stretching Raman signals, respectively. Signal intensities obtained were measured as functions of time and of depth into the nail. It was observed that the diffusion of D2O was more than an order of magnitude faster than that of PG-d8 and DMSO-d6. Normalization of the Raman signals, to correct in part for scattering and absorption, permitted semiquantitative analysis of the permeation profiles and strongly suggested that solvent diffusion diverged from classical behavior and that derived diffusivities may be concentration dependent. It appeared that the uptake of solvent progressively undermined the integrity of the nail. This previously unreported application of SRS has permitted, therefore, direct visualization and semiquantitation of solvent penetration into the human nail. The kinetics of uptake of the three chemicals studied demonstrated that each altered its own diffusion in the nail in an apparently concentration-dependent fashion. The scale of the unexpected behavior observed may prove beneficial in the design and optimization of drug formulations to treat recalcitrant nail disease. Compact structure of human nail revealed using red and green fluorescent dyes. Credit: Dr. Wing Sin Chiu. (Phys.org)—One of the biggest difficulties in treating nail disease is finding a topical drug that adequately penetrates through the nail. While some improvements in nail drug delivery have been made, they have been slow-going and still pose difficulties in treatment. A better understanding of drug delivery and solvent diffusion is needed. Parasite re-infection reduced by handwashing or nail clipping in Ethiopian children PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen © 2015 Phys.org