Insight into how pharmaceutical solvents diffuse through a human nail

first_img This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Insight into how pharmaceutical solvents diffuse through a human nail (2015, June 19) retrieved 18 August 2019 from In a recent study, Wing Sin Chiu, Natalie A. Belsey, Natalie L. Garrett, Julian Moger, M. Begoña Delgado-Charro, and Richard H. Guy from the University of Bath and the University of Exeter developed a method to acquire real-time semi-quantitative data on solvent diffusion through a human nail using stimulated Raman scattering microscopy. Their research appears in the Proceedings of the National Academy of Sciences.Human skin, hair, and nails are made of a hard, fibrous protein called keratin. Keratin provides a protective barrier keeping unwanted compounds from easily entering the body. However, keratin’s ability to protect the body also makes it an obstacle for topical drug delivery. Up to now, it has only been possible to obtain time- and position-dependent data on the movement of chemicals through the outermost 20μm of the nail. In an effort to better understand the diffusion of key pharmaceutical solvents through a nail, Chiu et al. used stimulated Raman spectroscopy (SRS) to trace the movement of dimethylsulfoxide (DMSO), propylene glycol (PG), and water through several human nail samples.Stimulated Raman spectroscopy is an imaging technique that was first reported in 2008 for detecting small amounts of chemicals, such as pharmaceuticals or metabolites, within biological systems without having to use fluorescent labels. Since SRS is based on matching laser frequencies to chemical vibrational frequencies, it is able to neglect the environmental background, making it a good technique for non-invasive biomedical studies. Furthermore, SRS scan time is fast enough for real-time measurements. Explore further Journal information: Proceedings of the National Academy of Sciences For D2O, the Raman wavelengths were tuned to the O-D stretching band at 2,500 cm-1. Signals were taken as a function of time (every 2.7 minutes after t=10 minutes). After about thirty-five minutes, D2O had diffused ~100μm into the nail. The authors report that this is the first time that this kind of rapid, real-time transport of water through a nail has been visualized.Studies with deuterated DMSO and PG showed that they took much longer to diffuse through the nail. While water took less than an hour to penetrate 100μm, after a day, DMSO and PG only penetrated 40-50μm into the nail.Data analysis showed that the solvents deviate from classical diffusion behavior as the time of diffusion increases. Quantitative analysis was performed by accounting for several factors, including nail curvature, sample movement, and solvent depletion at the surface. Scans were normalized to keratin’s –CH2 frequency and analyses showed no significant solvent depletion at the nail surface. For each of the solvents, as diffusion time increased, the concentration profile deviated from classical behavior (Fick’s Second Law). Based on calculations using experimental results, this behavior is characteristic of a time- and concentration-dependent diffusion coefficient. Additionally, the rapid diffusion of water compared to the other two solvents indicates that there is a likely a strong molecular size dependence on diffusion across the nail. Finally, SEM imaging confirmed that the solvents loosen the nail structure and increase nail roughness, indicating that the nail is weakened when exposed to the solvents for a long period of time, which may lead to increased solvent diffusion over time. Additional studies of the nanostructure of the nail may provide further insight as to why solvent diffusion into a human nail deviates from classical behavior.This paper reports for the first time real-time solvent behavior as it is absorbed into a human nail. These results elucidate certain factors in drug solvent and nail bed uptake that will help in drug discovery and the development of topical medicines for nail disease. Play Orthogonal views of D2O penetration into human nail as a function of time. Credit: PNAS, doi: 10.1073/pnas.1503791112 Keratin has a characteristic –CH2 stretch at 2,855 cm-1 that Chiu et al. used to normalize SRS signals from the nail samples. Studies were conducted using deuterated solvents to easily distinguish the solvent vibrational bands from those of the nail. Concentration is linearly related to SRS signal allowing for a semi-quantitative measurement of solvent diffusion. This technique is “semi-quantitative” because of signal attenuation from light scattering as sample depth increases. In this case, signals from deeper within the nail would underestimate the amount of chemical present because the signal is slightly weakened with increasing depth. More information: “Molecular diffusion in the human nail measured by stimulated Raman scattering microscopy” PNAS, DOI: 10.1073/pnas.1503791112AbstractThe effective treatment of diseases of the nail remains an important unmet medical need, primarily because of poor drug delivery. To address this challenge, the diffusion, in real time, of topically applied chemicals into the human nail has been visualized and characterized using stimulated Raman scattering (SRS) microscopy. Deuterated water (D2O), propylene glycol (PG-d8), and dimethyl sulphoxide (DMSO-d6) were separately applied to the dorsal surface of human nail samples. SRS microscopy was used to image D2O, PG-d8/DMSO-d6, and the nail through the O-D, -CD2, and -CH2 bond stretching Raman signals, respectively. Signal intensities obtained were measured as functions of time and of depth into the nail. It was observed that the diffusion of D2O was more than an order of magnitude faster than that of PG-d8 and DMSO-d6. Normalization of the Raman signals, to correct in part for scattering and absorption, permitted semiquantitative analysis of the permeation profiles and strongly suggested that solvent diffusion diverged from classical behavior and that derived diffusivities may be concentration dependent. It appeared that the uptake of solvent progressively undermined the integrity of the nail. This previously unreported application of SRS has permitted, therefore, direct visualization and semiquantitation of solvent penetration into the human nail. The kinetics of uptake of the three chemicals studied demonstrated that each altered its own diffusion in the nail in an apparently concentration-dependent fashion. The scale of the unexpected behavior observed may prove beneficial in the design and optimization of drug formulations to treat recalcitrant nail disease. Compact structure of human nail revealed using red and green fluorescent dyes. Credit: Dr. Wing Sin Chiu. (—One of the biggest difficulties in treating nail disease is finding a topical drug that adequately penetrates through the nail. While some improvements in nail drug delivery have been made, they have been slow-going and still pose difficulties in treatment. A better understanding of drug delivery and solvent diffusion is needed. Parasite re-infection reduced by handwashing or nail clipping in Ethiopian children PausePlay% buffered00:0000:00UnmuteMuteDisable captionsEnable captionsSettingsCaptionsDisabledQuality0SpeedNormalCaptionsGo back to previous menuQualityGo back to previous menuSpeedGo back to previous menu0.5×0.75×Normal1.25×1.5×1.75×2×Exit fullscreenEnter fullscreen © 2015 Phys.orglast_img read more

Best of Last Week – New way to detect dark matter a

first_img © 2015 Journal information: Scientific Reports Trio create artificial magnetic wormhole (—It was another good week for physics as Ian Shoemaker, until recently with the University of Southern Denmark, proposed a new theory, suggesting that if we want to detect dark matter, we might need a different approach—he believes that scientists should be looking for dark radiation signals that theoretically result from dark matter collisions. Also, another trio created an artificial magnetic wormhole—a three-layered sphere that makes it appears as if a magnetic field has suddenly disappeared and then reappeared somewhere else. In other news, a team of researchers in Rome and Geneva found a way to create tiny gears that increase light-to-work conversion efficiency by five orders of magnitude—by shining an LED light on tiny pinwheel-shaped gears floating on a liquid surface. Also, an international team of researchers came up with a way to fabricate hexagonal silicon, potentially leading to light-emitting semiconductors. They believe it could lead to new kinds of optical, electrical and superconducting materials. And another team at Cornell University reported on their efforts to explore the origins of energy in chemical reactions using experimental quantum chemistry.In unrelated news, a team of paleobotanists reported that they had identified what could be the mythical “first flower”—Montsechia vidalii, a plant that once grew abundantly in the Pyrenees and in the Iberian Range. Also, another team working at the Schoeneck-Kilianstaedten dig site in Germany reported that they had found evidence of a prehistoric massacre in Europe. In the interesting developments file, a team of researchers at the University of Texas Medical Branch at Galveston reported that they had developed a drug—a regenerative peptide—that protects against the deadly effects of nuclear radiation 24 hours after exposure. And there were reports, of course, of the Ashley Madison “cheater” files hitting the dark web—the hacker group made good on its promise to release data stolen from the site that specializes in providing a way for people to cheat on their partners.And finally, if you have ever found things getting weird when gazing into the eyes of a loved one for very long, you might have a lot of company, as a team of researchers has found that staring into someone’s eyes for a long time can cause hallucinations. Apparently, it happens to most people. Citation: Best of Last Week – New way to detect dark matter, a magnetic wormhole and staring found to cause hallucinations (2015, August 24) retrieved 18 August 2019 from Explore further (a) The field of a magnetic source (right) is appearing as an isolated magnetic monopole when passing through the magnetostatic wormhole; the whole spherical device is magnetically undetectable. (b) The wormhole is composed of (from left to right) an outer spherical ferromagnetic metasurface, a spherical superconducting layer, and an inner spirally wound ferromagnetic sheet. Credit: Scientific Reports 5, Article number: 12488 (2015) doi:10.1038/srep12488 This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Researchers simulate information signaling between cells

first_img Citation: Researchers simulate information signaling between cells (2015, October 5) retrieved 18 August 2019 from This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. (—Many natural systems are described by dynamics of traveling wavefronts. Sharp traveling fronts are employed in countless phenomena, including fluid convection, chemical reactions, and cellular phenomena. Living systems use front propagation encoded in biochemical reactions to communicate and perform computations, but these dynamics are difficult to study in three dimensions (i.e., in vivo). Thus, to understand how propagating gene expression fronts work in complex living systems, it is important to study how they work in minimal systems. Artificial cells act like the real thing More information: “Propagating gene expression fronts in a one-dimensional coupled system of artificial cells.” Nature Physics (2015) DOI: 10.1038/nphys3469AbstractLiving systems employ front propagation and spatiotemporal patterns encoded in biochemical reactions for communication, self-organization and computation. Emulating such dynamics in minimal systems is important for understanding physical principles in living cells and in vitro. Here, we report a one-dimensional array of DNA compartments in a silicon chip as a coupled system of artificial cells, offering the means to implement reaction–diffusion dynamics by integrated genetic circuits and chip geometry. Using a bistable circuit we programmed a front of protein synthesis propagating in the array as a cascade of signal amplification and short-range diffusion. The front velocity is maximal at a saddle-node bifurcation from a bistable regime with travelling fronts to a monostable regime that is spatially homogeneous. Near the bifurcation the system exhibits large variability between compartments, providing a possible mechanism for population diversity. This demonstrates that on-chip integrated gene circuits are dynamical systems driving spatiotemporal patterns, cellular variability and symmetry breaking. Explore further © 2015 Journal information: Nature Physics A group of researchers in Israel and the United States report in Nature Physics the results of a study of a one-dimensional array of artificial cells in a silicon chip—in essence, a system of coupled cells in which the researchers could implement reaction-diffusion effects and study how they propagate among cells.Artificial cells?Artificial cells are engineered systems of various kinds that simulate a number of functions of biological cells. In this case, the array of cells consists of 15 compartments inside which the researchers patterned gene circuits. The compartments simulate the microencapsulation of the biological membranes of cells, separating the internal cellular mechanisms from other “cells” while allowing the exchange of small molecules.Carved into a silicon substrate, the compartments were fed by a main flow channel and interconnected by fork-shaped capillaries. Cell extract from Escherichia coli was fed continuously through the main channel. The researchers were interested in how biological multicellular systems use traveling wavefronts to communicate. Signals dissipate over short distances within a medium, so cells accomplish long-range transmission of information by consecutive local cell-to-cell interactions. In living systems, the transmission models are too complex to study, but this isolated array of artificial cells revealed interesting dynamics likely applicable to the study of actual multicellular systems.Though front propagation has been studied in the past, yielding results that have applications in science and industry, the authors note that this is the first time anyone has created a synthetic, spatially coupled cellular system capable of long-range cell-to-cell communication. The first compartment was patterned with a small amount of starter protein construct, and as the medium flowed through the channels, the researchers found that the DNA starter initiated diffusion of the activator to the neighboring compartment. This created an autocatalytic reaction in which the neighboring compartment created a new source of activator. The researchers characterized expression-diffusion dynamics by measuring the timescales between the diffusion of proteins along the capillaries, which occurred over minutes, and the gene expression dynamics in the compartments, which changed over hours. In essence, the researchers created a system of autocatalyzing protein synthesis in which the activator signal cascaded through the compartments, which amplified it and diffused it to neighboring compartments. The authors write, “The spatial organization of DNA circuits together with short interaction length, set by the array geometry, will allow integrating long-range signaling with local information processing reactions based on gene expression, in analogy to multicellular systems, electronic circuits, and neural networks.”last_img read more

Physics pair show that Ising model can be used as a universal

first_img Journal information: Science (—A pair of physicists has shown that it is possible to transform disparate spin models into different types of just one simple model. In their paper published in the journal Science, Gemma De las Cuevas, with the Max Planck Institute for Quantum Optics and Toby Cubitt, with University College London, offer a proof to show that any spin model can be converted to the relatively simple Ising model. Stephanie Wehner with QuTech, Delft University of Technology offers a Perspectives piece on the work done by the team in the same journal issue, outlining the proof and explaining how and why a universal spin model would be useful. © 2016 The benefit of having a universal model, Wehner explains, is that it offers an alternative way for scientists to run their models, particularly on a computer. If a 3D model is extremely complex, for example, or requires an untenable number of cycles to run, there is a chance it could be configured to run as an Ising model. But she notes that it could also be used as a means for melding the work being done by physicists and computer scientists, helping to further explain the workings of nature. Explore further Citation: Physics pair show that Ising model can be used as a universal spin model (2016, March 11) retrieved 18 August 2019 from Spin models were first developed as a means to help explain the properties of magnetic materials—the magnetism in each atom originates from the spin of an unpaired electron within it. The first was created by Wilhelm Lenz, who handed it off to Ernest Ising, who used it to show that spins should undergo phase transitions below a certain temperature. Since that time, spin models have been developed for a wide variety of applications, perhaps most notably in particle physics. Now, in this new effort, De las Cuevas and Cutitt show that it is possible to transform any of these other newer models into the 2D Ising model, including 3D models.Their proof has two main parts, the first involved showing that any Ising model is equivalent to an instance of a satisfiability problem and showing a way to match such problems to an Ising model. The second part involved showing how any spin model could be converted to a satisfiability problem and then translated to an Ising model.center_img Scientists explain the theory behind Ising superconductivity More information: G. De las Cuevas et al. Simple universal models capture all classical spin physics, Science (2016). DOI: 10.1126/science.aab3326AbstractSpin models are used in many studies of complex systems because they exhibit rich macroscopic behavior despite their microscopic simplicity. Here, we prove that all the physics of every classical spin model is reproduced in the low-energy sector of certain “universal models,” with at most polynomial overhead. This holds for classical models with discrete or continuous degrees of freedom. We prove necessary and sufficient conditions for a spin model to be universal and show that one of the simplest and most widely studied spin models, the two-dimensional Ising model with fields, is universal. Our results may facilitate physical simulations of Hamiltonians with complex interactions. Universal models contain all models, just like white light contains all colors. Credit: Christian Hackenberger Universal models contain all models, just like white light contains all colors. Credit: Christian Hackenberger This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

Sediments in Gulf of Naples reveal impact on Roman water distribution after

first_img Lead in ‘tap-water’ in ancient Rome up to 100 times more than local spring waters © 2016 Painting by Joseph Mallord William Turner (between 1817 and 1820) Vesuvius in Eruption, watercolor. Credit: Yale Center for British Art. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. To bring water to cities, the early Romans built vast waterworks systems using aqueducts and lead pipes—the water that was delivered, unbeknownst to the Romans, contained some amount of lead which in addition to making its way into the bodies of those who drank it, also made it into the ground or other water systems via sewage. In the case of the cities and towns around Naples, sewage was piped to certain locations where it was dumped directly into the harbor which resulted in sediment build up, some of which contained lead particles. Modern researches studying sediment cores can analyze the different layers of sediment and note the different amounts of lead in it and the differences in the types of lead, which can offer information about the amount of water brought into the system, and in this case, the changes to the system that came about.In studying their sediment core samples taken from the harbor, the researchers found marked changes in lead particles immediately after Mount Vesuvius erupted, likely, they suggest, because the eruption either clogged pipes, or destroyed some of the water delivery system. Differences in isotopic composition, they noted suggested lead pipes had been brought in from different locations to replace those that had been damaged. They noted also that the original water system had remained in place for approximately 15 years after the eruption before it was finally replaced. The team also found evidence of a continually expanding water system until approximately the fifth century, when natural disasters and invasions led to a sharp decline in upgrades.The researchers suggest their techniques could be used in other parts of the world, not just the area once covered by the Roman Empire—to better understand population changes, or other events that had an impact on the people that lived there. More information: Hugo Delile et al. A lead isotope perspective on urban development in ancient Naples, Proceedings of the National Academy of Sciences (2016). DOI: 10.1073/pnas.1600893113AbstractThe influence of a sophisticated water distribution system on urban development in Roman times is tested against the impact of Vesuvius volcanic activity, in particular the great eruption of AD 79, on all of the ancient cities of the Bay of Naples (Neapolis). Written accounts on urbanization outside of Rome are scarce and the archaeological record sketchy, especially during the tumultuous fifth and sixth centuries AD when Neapolis became the dominant city in the region. Here we show that isotopic ratios of lead measured on a well-dated sedimentary sequence from Neapolis’ harbor covering the first six centuries CE have recorded how the AD 79 eruption was followed by a complete overhaul of Neapolis’ water supply network. The Pb isotopic signatures of the sediments further reveal that the previously steady growth of Neapolis’ water distribution system ceased during the collapse of the fifth century AD, although vital repairs to this critical infrastructure were still carried out in the aftermath of invasions and volcanic eruptions.center_img Journal information: Proceedings of the National Academy of Sciences Citation: Sediments in Gulf of Naples reveal impact on Roman water distribution after Vesuvius eruption (2016, May 17) retrieved 18 August 2019 from Explore further (—A team of researchers with members from France, the U.S., the U.K. and Italy has found evidence of disruptions to the water delivery system in the area around Naples after the eruption of Mount Vesuvius in AD 79. In their paper published in Proceedings of the National Academy of Sciences, the team describes their testing of sediment cores taken from the harbor at Naples, what they found and what their study has revealed about the history of the area.last_img read more

Images made of relativistic electrons trapped in graphene quantum dots

first_img Journal information: Nature Physics (—A team of researchers with the University of California, MIT, Lawrence Berkeley National Laboratory and the National Institute for Materials Science in Japan has created images of relativistic electrons trapped in graphene quantum dots. In their paper published in the journal Nature Physics the team describes how they achieved this feat and where they plan to take their work in the future. Researchers find electron chirality in graphene impacts current flow As the many unique properties of graphene continue to unfold, scientists seek new ways to harness and eventually make use of them. One such use might be to control electrons to allow their use in nano-scaled devices, which could also inadvertently lead to a deeper understanding of Dirac fermions. In this new effort, the researchers have made progress in that area by devising a means for capturing and holding electrons and for creating images of the result.Obtaining images of electron waveforms has thus far been particularly difficult—virtually all existing methods have resulted in too many defects. To get around such problems, the researchers took another approach to capturing the electrons. They first created circular p-n junctions by sending voltage through the tip of a scanning tunneling microscope down to a graphene sample below. At the same time, they also applied voltage to a slab of silicon underneath the piece of graphene, which was kept separated by a layer of silicon-oxide and a flake of boron nitride. Doing so caused defects in the boron nitride to ionize, resulting in charges migrating to the graphene.To create images of those charges, the researchers placed a scanning tunneling microscope tip just above the surface of the quantum dot, which allowed for measuring the tunneling current—moving the tip to different locations allowed for taking multiple measurements which when taken together allowed for creating an image.The new method, the team suggests, could be used as the basis for developing systems that are more complicated, such as those with multiple quantum dots. They next plan to investigate using their technique with bilayer graphene samples, which hold far more Dirac charge carriers to see if they reflect when they impinge on the p-n junction barrier in expected ways. The STM tip spatially probes Dirac fermion wavefunctions in the presence of the p–n junction. Credit: (c) Nature Physics (2016). DOI: 10.1038/nphys3805 More information: Juwon Lee et al. Imaging electrostatically confined Dirac fermions in graphene quantum dots, Nature Physics (2016). DOI: 10.1038/nphys3805AbstractElectrostatic confinement of charge carriers in graphene is governed by Klein tunnelling, a relativistic quantum process in which particle–hole transmutation leads to unusual anisotropic transmission at p–n junction boundaries. Reflection and transmission at these boundaries affect the quantum interference of electronic waves, enabling the formation of novel quasi-bound states. Here we report the use of scanning tunnelling microscopy to map the electronic structure of Dirac fermions confined in quantum dots defined by circular graphene p–n junctions. The quantum dots were fabricated using a technique involving local manipulation of defect charge within the insulating substrate beneath a graphene monolayer. Inside such graphene quantum dots we observe resonances due to quasi-bound states and directly visualize the quantum interference patterns arising from these states. Outside the quantum dots Dirac fermions exhibit Friedel oscillation-like behaviour. Bolstered by a theoretical model describing relativistic particles in a harmonic oscillator potential, our findings yield insights into the spatial behaviour of electrostatically confined Dirac fermions.center_img © 2016 Explore further Citation: Images made of relativistic electrons trapped in graphene quantum dots (2016, July 15) retrieved 18 August 2019 from This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more

US Appeals Court In Chicago Again Upholds La

first_imgU.S. Appeals Court In Chicago Again Upholds Laws Banning… by NPR News Bobby Allyn 8.29.19 7:00pm A federal appeals court on Thursday upheld Cook County, Ill., gun laws, including a ban on assault weapons and large-capacity magazines, affirming a lower court decision that found the regulations to be constitutional.The 7th U.S. Circuit Court of Appeals held that two gun owners, who sued over the gun control measures in the county where Chicago is located, “have not come forward with a compelling reason to revisit” since the last time the same court examined a similar challenge — out of the Chicago suburb of Highland Park, which was also sued after passing an assault weapons ban. In that case, the 7th Circuit said that the Second Amendment “does not imperil every law regulating firearms.”In 2015, the U.S. Supreme Court declined to consider the case. That meant the appeals court’s decision that local governments have latitude in regulating firearms stayed in place, and on Thursday, the three-judge panel refused to revisit that decision.The plaintiffs, Troy Edhlund and Matthew Wilson, argued that Cook County’s ban on assault weapons was so vague that it could potentially make it illegal to possess semi-automatic firearms that were not assault weapons. The duo said the gun regulations impinged on their right to bear arms. In contending that the Cook County case was distinct from the Highland Park challenge, lawyers for the two gun owners wrote that the “frequency of the criminal threats faced” in the Chicago area should be considered in deciding whether restrictions infringe on a gun owner’s Second Amendment rights. The court, however, did not find that logic persuasive, saying the gun laws did not prevent citizens from acquiring other types of weapons for self-protection. “Our discussion of self-defense focused instead on the availability of other means for citizens to defend themselves,” the court wrote. “This is a question answered by the particular locality’s laws, not by its crime rates.”Gregory Bedell, a lawyer for Edhlund and Wilson, did not return a request for comment by NPR. The case can be appealed to the U.S. Supreme Court, which has become more conservative since the justices rejected the Highland Park case in 2015.Copyright 2019 NPR. To see more, visit NPR. M. Spencer Greenlast_img read more

An ordinary fare

first_imgBetween 1 to 2 pm only on Mondays madam, says the voice on the other end when I call up to confirm if walk-in is an option for outsiders in Rajasthan Bhawan’s canteen. Sensing my interest in the Rajasthani cuisine, he immediately adds that anybody could walk-in on any day of the week but the Rajasthani thali or platter is a once-a-week affair at the canteen. So, I waited for almost a week for that preordained lunch hour to gorge on the delicious Rajasthani platter here in the Capital. And when the day approached, monsoon, with all its splendour, had finally arrived in the Capital, casting a perfect setting for my lunch. I started out early to make it on time; well, I had only a bracketed hour-long time for the meal.  Also Read – ‘Playing Jojo was emotionally exhausting’Walking inside the foyer of Rajasthan Bhawan, I glided down a step of stairs to find the canteen in a corner. A sizeable window in the canteen peeps into a hall with tables dressed in white linen and plastic covers set around wooden seats. Amongst the first few to arrive, I was delighted to make it on time. The attendant however informed me that I was early for lunch and food will be served by 1 pm. By and by, the hall started filling up with seemingly in-house guests and bureaucrats and it was half past 1 by the time the thalis made their first appearance. Indian Standard Time dutifully observed! Turning into a one man army, one attendant whizzed around the hall distributing thalis. By the time my moderately warm thali arrived, it was well past 1:30 pm.  Also Read – Leslie doing new comedy special with NetflixI scanned the thali and noticed the special daal-baati-churma alongside a dish of mix vegetable, gatta curry (gram flour dumplings in curry), rice and chapatis. Baati was bang on, crunchy and smoky in texture and the finely coarse churmawas mildly sweet. But what remained elusive was the conspicuous absence of ghee in the course. What stood out for me was the simple and tangy gatta curry.I have never imagined eating daal-baati-churma without ghee; it seems dry and takes down the entire experience by several notches. Well, the food came in late, the ghee never arrived, and there was nothing in the tapestry or up on the walls to hook onto.  Give this one a miss, without batting an eyelid.Meal for two : Rs 220 onwardslast_img read more

Sufi music can never be commercialised

first_imgHow did music come calling to you?Music is not a mere profession to us, it is a legacy we are carrying which has been blessed to us by our ancestors.Have qawali and sufi music got their due in the music circuit?Qawali and sufi music has its own place in the music circuit. Sufi and qawali are not commercial rather they are integral to our tradition.Are you open to Bollywood offers after Rockstar?After the success of music of Rockstar we got a brilliant response from the audience and critics. Yes we are open to work on more Bollywood assignments, infact we are working on few things, will soon announce when something positive develops. Also Read – ‘Playing Jojo was emotionally exhausting’What does music mean to you?Music to us is our passion and obligation to do justice everytime we perform. As our ancestors has earned respect on the basis of this only, so its our responsibility to take it further.Do you follow any other Indian or foreign musicians. If yes, what do you like in them?We do not to name of any artist but we really follow sufi songs, shayari and chants of Amir Khusro.Have you thought about coming out with your own label or album? Also Read – Leslie doing new comedy special with NetflixCurrently we are planning something, but is it has a long way to go.Would you ever like to experiment with your genre of music or try fusion?It’s great to be a versatile and we respect all the genres of music be it fusion or some other. But right now we are not planning to experiment with our genre.How has the journey been for all these years?Our journey, right from the start, was tough. Firstly to maintain the name of our ancestors was a big challenge for us. The love and admiration we got from the audience just cannot be expressed in words.How does the audience react to your music on international shores. Do they accept it well?It really makes us proud that people in other countries love sufi music and its amazing to see their attendance at the concerts. Sometimes it happens that they don’t understand the music and lyrics completely, but is really great to see their admiration towards us.last_img read more

Mind over matter

first_imgThis may be his debut solo art show but 24-year-old Pallav Chander is not new to the world of arts. He has regaled many an audience with his portrayal of a woman in the play Mahim Junction, has created larger-than-life sets for his other theatrical productions and been a witness to India’s contemporary art scene as the only child to Kanchan Chander, a well-known artist of our times.It’s no wonder then, that even for his debut art show, titled Decoding A Dyslexic Mind that will be held at Visual Arts Gallery, India Habitat Centre, New Delhi from March 1 till March 6, 2014, 10 a.m. to 6 p.m., Pallav shows a remarkable confidence in the autobiographical 35-odd works which include oils on canvas, acrylic on canvas and paperworks. Transcending mediums and genres – he has created textural, semi-abstract figurative works and abstracts too.  Chander’s imagination is inspired by mainly one theme – his own life. Also Read – ‘Playing Jojo was emotionally exhausting’That he is dyslexic and a large part of his work features hands is Chander’s may not be ‘a direct message to not consider dyslexics as abnormal’, but Pallav does concede that he was the brunt of many taunts as a school-going child and Aamir Khan’s Taare Zameen Par did ‘help me a lot’. As art curator Roobina Karode writes in the catalogue essay: ‘Decoding a dyslexic mind is about a particular mind, about Pallav Chander, a young artist who, one fine day snapped out of memories of his uncomfortable school days and grew up to do what he enjoyed the most- make art. While still in school, Pallav had experienced a certain lack of speed in comprehending and writing and these grasping difficulties instilled a certain anxiety towards social interaction and team work in the classroom. As he came to be aware of his disability, but had not yet learnt to come to terms with being dyslexic, he shied away from people, often due to peer pressure and the fear of being judged. With his mother’s constant effort and encouragement Chander was first introduced to performing arts and theatre workshops in the city, and this brought a gradual but dramatic change in his persona, as he had to be on stage and give his role the required emotion in front of an audience. His appetite for the arts was reinforced by his experiences doing theatre.’ Also Read – Leslie doing new comedy special with Netflix’Of course it was tough as a dyslexic child, and all these works are almost autobiographical. Not only do they reflect my present state of mind but also my growing up years after my parents separated.  Hands came into my work from my experiences in the UK. Each and every hand for me is like a memory, a moment from my life which I would want to remember,’ says Chander.WHERE: Visual Arts Gallery, IHC (till 6 March); Passage Art, Khan Market (7 March to 31 March)last_img read more

To martyrdom

first_imgCommemorating the martyrs of 1965 war, Doordarshan Delhi, has conceptualised a programme Smarananjali for telecast on Doordarshan National channels.  It will be a specially woven tapestry of music, songs and dance that reflects the gravity of the sacrifice and will capture the sincere gratitude of the nation. It will feature artistes like violin maestro L Subramanium and singer Kavita Krishnamurthy, Pankaj Udhas and Suresh Wadkar. Performance by theses artistes from Subramaniam Foundation will be interlaced with specially choreographed dance performances of memorable patriotic songs by Manjula Parmesh and group. Adding to it is the on spot painting by renowned painter, B S Verma and a dance by soldiers from the Madras Engineering Group (MEG). Union Minister for Defence, Arun Jaitley, Union Minister for Information and Broadcasting Prakash Javadekar , the  three Chiefs staff of the Army, Navy and Air force, Paramilitary forces  and other guests will grace the occasion by their presence.last_img read more

Patient dies at Medica Superspecialty Hospital family cries negligence

first_imgKolkata: The family members of a 51-year-old woman, who died of alleged medical negligence at Medica Superspecialty Hospital, lodged a complaint with the West Bengal Clinical Establishment Regulatory Commission (WBCERC).In his complaint, the victim’s husband Pradip Paul mentioned that the patient was wrongly treated during her dialysis in the hospital. He lodged specific complaint against Dr Anupam Roy, who treated the patient. WBCERC has started a detailed probe into the incident. Also Read – Rain batters Kolkata, cripples normal lifeThe victim, Sukla Paul, a resident of Dakshin Dinajpur was admitted to the hospital on 13 July with kidney-related ailments.It was learnt that the patient, a known case of hypertension with chronic kidney disease, attended Nephrology OPD on July 13. The patient was kept on mechanical ventilation and hemodialysis had been conducted on her for last the two weeks.According to the press statement issued by the hospital authorities, the patient was being treated for respiratory failure due to Acute Respiratory Distress Syndrome and severe co-agulopathy with renal failure. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedThe hospital also claimed that the patient was in a critical condition when she was admitted to Medica. “Despite our best efforts, the patient could not be saved and she passed away on July 29,” said the press statement.According to the hospital authorities, the patient had an uneventful hemodialysis procedure after which she was admitted and kept on observation as she complained of swelling in right side of her neck and difficulty in breathing. Post-procedure, her vitals were normal and chest X-Ray did not reveal any significant abnormalities. She was transferred to the Intensive Care Unit (ICU). It was noticed that she had a hematoma on the right side of the neck around the initial puncture site, which was managed with usual conservative methods.The patient’s blood investigations revealed low hemoglobin levels with abnormal clotting parameters, for which she was transfused blood. Cardio Thoracic and Vascular Surgery (CTVS) was consulted for suspected neck hematoma and they advised a CT Angiogram of the neck and to continue supportive care.She was continued on regular dialysis and regular consultations with CTVS team, Critical Care Team and a Hematologist. Medical Boards were contacted on multiple occasions in presence of consultants from different specialities, along with the patient’s next of kin. After detailed investigations, it was found that she has a rare form of Coagulation Disorder due to preformed antibody and inhibitors against blood clotting factors.last_img read more

Thundershower lightning hit four South Bengal districts parts of city

first_imgKolkata: A thundershower accompanied by lightning hit four South Bengal districts and some parts of the city on Sunday morning saving residents from the hot and humid condition.The rain has brought down the temperature by a few notches. Districts like North 24-Parganas, South 24-Parganas, Nadia and Murshidabad received moderate to heavy rainfall coupled with lightning from Sunday morning.The rain lasted for nearly two hours and the city remained cloudy. As the day progressed, the city dwellers witnessed light to moderate rainfall. Also Read – Rain batters Kolkata, cripples normal lifeA strong wind was blowing at 40-60 km/hour in some parts of South Bengal on Sunday.The regional meteorological centre at Alipore has predicted a possibility of thunderstorm in some South Bengal districts on Monday as strong moisture-laden southwesterly wind would blow in the area, creating a favourable environment for a storm.The city may also receive scattered rainfall in the next 24 hours as predicted by the weather office. It may be mentioned that vehicular movement on various stretches of the city remained slow following the rain. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedAccording to Alipore MeT office, there may be heavy rainfall in some North Bengal districts in the next 24 hours.It may be mentioned that the city witnessed moderate to heavy rainfall a few days ago due to cyclonic circulation that was earlier hovering over Gangetic Bengal.As a result, some parts of the city and adjoining areas witnessed scattered rainfall for the past few days. Situation was further intensified in South Bengal after a low pressure trough was formed over Bay of Bengal.According to a weather expert, the formation of thunder cloud over Gangetic plains has contributed to the rains.Multiple thunderstorms may swept through some parts of South Bengal till Monday.last_img read more

Keeping Patola traditions alive

first_imgSarees are known as the flavour of all seasons, and when they are made of natural colours and pure silk one cannot help but keep their eyes glued at the drapes. Recently, the Chandigarh Press Information Bureau took an initiative to allow visits and help witness the live experience of saree making at Patola house in Patan (Gujarat). There are around 700 families who have been indulged in this profession since 11th century but now it is only the Salvi family that has kept the tradition of Patola (double ikat) alive. Though the younger generation is pursuing different professions including that of an architect, an engineer and a physiotherapist, they still work as weavers and are fully trained in the process. Its unique qualities like gorgeous colours, designs and durability lures connoisseurs. The ready stuff has no reverse side as both the sides have equal intensity of color and design. Making a saree is a very complicated process as it requires mental precision along with mathematical calculations as a single thread can result in deformed pattern. The whole process – right from unfolding the silk to the finished product – is done manually, without the help of machines, therefore it takes six months to an year to complete a single piece. The range of these sarees starts from Rs 2 lakhs and can go up to any amount depending on the work done on it. Due to the lack of silk production in our country, mulberry silk is imported from other countries to make Patolas. All the silk threads are tied separately as per the design. The process includes tying, untying, retying and dyeing. The threads are put together in a sequence on the loop so that the design becomes evident. Thereafter, the saree is woven on a primitive hand operated harness loom made out of rosewood and bamboo strips. According to Rohit Bhai Salvi, the leader of the family, natural vegetable colours are used for making the piece. Because of a double resist in the dying process, the colour of these sarees never fade. Around 10 centuries ago, King Kumara Pala of Gujarat brought the expertise of Patolas from Maharashtra to make these sarees. But now it is the 16th generation of Salvi family that is trying hard to keep the tradition alive. To inform and aware people about this tradition, the family has converted their ancestral house into a museum where around 100 visitors step in everyday. The family had been a recipient of many awards for keeping the tradition alive. These include the Shilp Guru Award 2002, which was conferred upon Vinayak K Salvi by Dr Abdul Kalam, then President of the country; the National Award of Master in 1965 and CraftsMan of the year award in 1993. The President of India has conferred the national awards for Master Craft Persons to these very Salvi’s in 1978, 1987 and 1997. The family had also participated in regional trading workshop for women dealing with modern and traditional dyeing, weaving silk in Asia at Bangkok, Thailand in 1987 and in Haebru Asia Kasuri Road Festival in Okinawa, Japan in November 2000. They had also been honoured by Vishvakarma Award – 1984; National Award – 1987; and National Award – 1997 by then Prime Minister Atal Vihari Vajpayee and many more.last_img read more

Businessman shot at in Dholahat battles for life

first_imgKolkata: A businessman was shot at in South 24-Parganas on Saturday night.The injured person was shifted to a Kolkata hospital as his condition became serious.The businessman was shot at on Saturday night at Dholahat in South 24-Parganas. The injured person identified as Pulakesh Mondal was returning home riding his bike. Near Milan More area, a few miscreants blocked his way and tried to snatch his valuables away. Primarily, the miscreants tried to take away the mobile phone but were resisted by Mondal. When Mondal got down from the bike and tried to stop the miscreants, one of them fired a round of bullet aiming Mondal and fled the scene. The bullet hit Mondal on the left side of his chest and he fell on the ground. Hearing the sound of a bullet being fired, locals ran to Mondal and rushed him to Diamond Harbour Sub-Divisional Hopsital. Later on Saturday night, Mondal was shifted to a hospital in Kolkata. None has been arrested in this case till Sunday night.last_img read more

NRS removes giant size tumour from patient after 3hour surgery

first_imgKolkata: A team of doctors from NRS Medical College and Hospital has successfully removed a tumour weighing around five kg with a diameter of 11 cm from the lower abdomen of a 27-year-old woman from Murshidabad.The victim, Nargis Begum, a resident of Raninagar area of the district was admitted to NRS Medical College and Hospital on 8 January. After performing necessary tests the doctors found a big size tumour stretching from her pelvis up to the kidneys, almost blocking her food pipe. Also Read – Speeding Jaguar crashes into Mercedes car in Kolkata, 2 pedestrians killedThe patient first visited the Outdoor department after which she was advised to get admitted. The doctors decided to conduct a surgery to remove the tumour and it was not easy as there was a possibility of organs being affected with high-risk of tumour bleeding. The doctors informed that the tumour gradually grew over a period of two years and finally took the shape of a football. A team of doctors took all precautionary measures before conducting the operation. Also Read – Bose & Gandhi: More similar than apart, says Sugata BoseThere was a possibility of large intestine getting damaged while removing the tumour but the doctors successfully managed to remove it after three hours without affecting any other organ. The tumour was touching the left ovary of the patient and close to the urinary tract. The health condition of the patient is improving and she is being provided with liquid food. According to the hospital, the patient would be discharged in a few days. “The prevalence of such a tumour is found in every 6000-7000 patients. In most of the cases, that big a tumour has various roots which is why it becomes difficult for the doctors to remove but here, the tumour was could be completely removed as it had no major roots attached to other organs,” a senior official of the hospital said.last_img read more

Eat right to keep acne away

first_imgHave acne trouble? A balanced diet along with a healthy lifestyle can help you curb it, say experts. Experts tell what all one should eat to keep acne at bay: -Brown rice: Brown rice is a rich source of vitamin B, protein, magnesium, and several antioxidants. For acne, vitamin B acts as our skin’s stress fighter, which will help regulate hormones levels and prevent the likelihood of breakouts. -Garlic: Garlic is another super food that helps fight inflammation. Garlic is full of a naturally occurring chemical called allicin, which kills off many harmful bacteria and viruses your body might be fighting, so its proven to be good for reducing inflammation in acnes. Also Read – Add new books to your shelf-Broccoli: It is the perfect skin clearing food. It contains health building properties like vitamins A, B complex, C, E, and K. These antioxidants fight radical damage which will assist with the luminosity of your skin. -Fish: Known to be a very good source of omega-3 and 6-fatty acids, fish is excellent for an acne prone skin. These acids reduce inflammation in the skin. Sardine and salmon are very good for skin. -Nuts: Deficiencies in minerals such as zinc and selenium have been linked to acne. Most nuts contain selenium, vitamin E, copper, magnesium, manganese, potassium, calcium and iron, which are all essential for healthy skin. Also Read – Over 2 hours screen time daily will make your kids impulsive-Fennel: If you are looking for the perfect natural skin cleanser, eat fennel. This licorice-tasting root vegetable can improve digestion, reduce swelling and help to flush out excess fluids and toxins in your skin. -Green tea: Many studies show that green tea helps fight acne. Drink more green tea throughout the day, and try applying cooled tea bags or a cloth dipped in cooled green tea to acne-prone areas of your face for 10-15 minutes. -Red grapes: The fruit and seed contain powerful natural chemicals and antioxidants that have been shown to treat inflammatory skin conditions such as psoriasis and eczema. On top of this, grapes can also help to control the side effects of allergic reactions on skin. -Alfalfa sprouts: It looks like grass, but these sprouts are packed with valuable, skin-clearing nutrients. Alfalfa sprouts contain live enzymes which help fight inflammation. -Foods rich in vitamin A and carotenoids: Carotenoids are used in anti inflammatory drugs for treatment for acne. Rich sources of carotenoids include carrot juice, carrots, spinach, kale, cantaloupe, vegetable soup, mangos, papaya, instant fortified oatmeal, frozen peas and tomato juice. Fresh and canned peaches and red bell peppers provide modest amounts of carotenoid.last_img read more

KMC to refer serious dengue cases to staterun hospitals

first_imgKolkata: The Kolkata Municipal Corporation (KMC) will refer serious dengue cases to the state-run hospitals, which was decided at a high-level meeting held between senior civic officials and the superintendents of different state-run hospitals and senior officials of the state Health department. The meeting was presided over by Deputy Mayor Atin Ghosh.The civic authorities have dengue clinics in 144 wards and if any serious patient is found attending the clinic, he or she would immediately be referred to any state-run hospital located in the vicinity. In North Kolkata, cases will be referred to R G kar Medical College and Hospital. The civic authorities have requested the hospital superintendents to ensure that the patients referred by KMC are not refused admission. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataAs the KMC’s motto is zero mortality in dengue, the senior civic officials have urged people to get in touch with the dengue clinics and get their blood tested if they are found suffering from fever. The KMC dengue clinics are not only well equipped but the patients are also treated following WHO guidelines. The KMC officials regretted that as blood tests in the dengue clinics are free, people do not take them seriously. The KMC has health clinics in every borough, manned by specialised doctors. People suffering from diabetes are treated and blood tests and medicines are given to them free of cost. It may be mentioned that the KMC has launched special drives to eradicate dengue in the city. Twenty wards have been declared vulnerable and drives are being carried out in these wards regularly.last_img read more

Dont stereotype us Women sex workers urge Indian showbiz

first_img“I am a woman first and then a sex worker,” Kiran Ramchandra Deshmukh, 40, says with pride, in the hope that the world treats women like her with equality, dignity and respect. Kiran, a sex worker for over 20 years in Maharashtra, notes how the world of showbiz has portrayed sex workers over the years and isn’t impressed by the stereotyping. She takes offence at the dialogue ‘Aurat maa hoti hai, bahen hoti hai, patni hoti hai, dost hoti hai… aur jab woh kuch nahi hoti, toh tawaif hoti hai (woman is a mother, a sister, a wife, a friend. When she is nothing, she is a prostitute) from the 2002 film Devdas. Also Read – Add new books to your shelf”According to the dialogue, we don’t even deserve to be called women? That’s not fair. I can proudly say that I am a woman,” said Kiran. Renuka, another sex worker, has urged filmmakers not to show them as “use and throw” objects – as it happened in Salman Khan’s movie Chori Chori Chupke Chupke on surrogacy. Indian filmmakers have time and again delved into the life of women sex workers. Mughal-e-Azam, Mausam, Mandi, Devdas, Chandni Bar, and Begum Jaan are movies that have delved into their world, but sex workers and activists say these films do not reflect the real world. Also Read – Over 2 hours screen time daily will make your kids impulsiveSocial activist and lawyer Aarthi Pai says mainstream cinema has done a lot of damage to “the identity of sex workers”. “There has been some niche cinema which has attempted to show sex workers in a much more positive light, but most of the movies have shown them in dangerous type of stereotyping. Dangerous because it has harmed sex workers over the years. “This stereotype of sex workers hanging out in verandahs and showing their breasts, chewing betel is one which dominates public imagination. Sex workers are of different types and they have different realities. Unfortunately, great injustice is done to them through the movies.” Kiran said it is a reality that not everyone is forced into sex work. “Many women like me are willingly doing it to earn our livelihood. Even we have the right to say ‘No’.” Filmmaker Madhur Bhandarkar, whose deft handling of a story of a bar dancer won a National Award, says people shouldn’t forget sex workers are humans too. “They are also humans. They are being discriminated in our society. People are not willing to give them a house… They are a part of our society and we should accept them with open arms.” Most recently, Tabrez Noorani’s Love Sonia took a deep dive into the world of human trafficking. Actress Richa Chadha, who played a brothel owner in the film, said in an interview: “Bollywood is as responsible as society is, in stereotyping sex workers… Very few films have depicted the truth about this bleak world.” Love Sonia protagonist Mrunal Thakur calls for films which create a powerful impact on society and make people more educated and aware. “What we see in the films is just a fraction of what these girls go through in life.”last_img read more

CM to inaugurate 44th Book Fair on January 29 next year

first_imgKolkata: The 44th International Kolkata Book Fair (IKBF) will be inaugurated by Chief Minister Mamata Banerjee on January 29, 2020. The venue for next year’s book fair will be Salt Lake Central Park, with Russia being the theme country.”In 2020, the IKBF will start two days earlier than 2019. The Chief Minister has assured us that she will formally inaugurate the fair on January 29,” said Sudhansu Dey, director of Publishers and Book Sellers Guild, which hosts the IKBF every year. Dey met Banerjee at her chamber in the state legislative Assembly on Tuesday and finalised the inauguration date. The fair will be held for 12 days. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataIt may be mentioned that the IKBF 2019 that started from January 31, witnessed a record sale of books worth Rs 21 crore and witnessed a turnout of 23 lakh visitors. Guatemala was the theme country for this year’s book fair. Several countries from across the world attended this year’s edition of IKBF, which witnessed participation of authors from Russia, Costa Rica, Spain, Scotland, Australia, Argentina, Bangladesh and Guatemala. It may be mentioned that the IKBF had shifted to the Salt Lake venue in 2017, with the state government taking up a total renovation of the Milan Mela ground opposite Science City, which used to be the venue earlier.last_img read more